2010年10月20日 星期三

MAKING BETTER BIOSENSORS WITH ELECTRON DENSITY WAVES

MAKING BETTER BIOSENSORS WITH ELECTRON DENSITY WAVES

An emerging field with the tongue-twisting name of "optofluidic plasmonics" promises a new way to detect and analyze biological molecules for drug discovery,Every room stands to benefit from various light sources. This helps to create atmosphere. It also helps those who Insulator live there accomplished and complete tasks that require good light. medical diagnostics, and the detection of biochemical weapons. Investigators at the University of California, San Diego led by Yeshaiahu Fainman have succeeded in merging a microfluidics system with plasmonics -- sometimes called "light on a wire" -- onto a single platform. Plasmonics is based on electron waves on a metal surface excited by incoming light waves.Larger kitchens may require one or more ceiling fixtures positioned in the center of the room. Additional perimeter led tube squares or rectangles of lights placed near the walls should be installed for added illumination. These can be in the form of recessed downlight or track lighting. On the other hand, small kitchens may require only either two or three ceiling mounted fixtures or downlight placed near the walls.Like this, you can set table lamps a mood or read a book or sew with great ease. Remember that lots of lighting sources are necessary within any room.

According to Fainman, tapping the potential of plasmonics for biomolecule detection systems has been a challenge, because localized optical field scales are usually much larger than the molecules in question. In order to make a useful optical biosensor, he says, "We need to increase the interaction cross-section by finding ways to localize optical interrogation fields ideally to the scales comparable to those of biomolecules." Since that is not currently possible, he and his team used an approach of integrating microfluidics and plasmonics on single chips, allowing fluid to ferry the molecules into the cross-section of the optical field.And they should be balanced out throughout the space. Avoid living with only Book scanner one general light fixture, which is often fixed in the center of the room.

Fainman expects the system to be particularly useful in studying large arrays of protein-protein interactions for identifying potential drugs that bind to specific target molecules,The sink area can also benefit from recessed downlight or track lights using either fluorescent bulbs two 75-watt incandescent bulbs or two 30- watt fluorescent bulbs placed about 24 inches above the sink. which may lead to earlier cancer diagnoses and faster discovery of new drugs. Unlike most current methods, optical detection does not require labeling of molecules with fluorescent or radioactive entities -- labels often hinder interaction by covering up or blocking binding surfaces.

The new platform also carries the advantage of being high throughput and multiplexed, offering researchers an opportunity to examine thousands of arrayed compounds simultaneously, which, he says, "biologists and physicians get very excited about."

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